^[a] The Ravens traded their original second- (No. 62 overall) and fifth- (No. 165 overall) round selections, along with one of their sixth-round selections (No. 199 overall; originally acquired in a trade that sent wide receiverAnquan Boldin to the San Francisco 49ers) to the Seattle Seahawks in exchange for the Seahawks' second-round selection (No. 56 overall).
Due to a conflict involving the Orioles's schedule, the Ravens opener the regular season on the road against the Broncos in what would be the first time a defending Super Bowl champion team has done so since the Buccaneers in 2003 when they opened their regular season against the Eagles. This would be a rematch of last year's AFC Divisional game.
The Ravens drew first blood when Joe Flacco found Vonta Leach on a 2-yard touchdown pass to take the lead 7–0 in the first quarter for the only score of the period. The Broncos would tie the game in the 2nd quarter with Peyton Manning finding Julius Thomas on a 24-yard pass to take the game to 7–7. The Ravens moved back into the lead when Ray Rice ran for a 1-yard touchdown to make the score 14–7. Peyton would find Julius again on a 23-yard pass to make the score 14–14 for another tie before the Ravens kicker Justin Tucker nailed a 25-yard field goal to make the score 17–14 at halftime. In the 3rd quarter, the Broncos went right back to work as Peyton found Andre Caldwell on a 28-yard touchdown pass to take a 21–17 lead followed up with finding Wes Welker on 2 consecutive passes from 5 yards and 2 yards out for an increase in the lead first to 28–17 and then to 35–17. Later on in the quarter, Peyton would find Demaryius Thomas on a 26-yard pass to increase the lead to 42–17. The Ravens tried to rally a comeback in the last quarter, with Flacco finding Marlon Brown on a 13-yard pass to shorten the Broncos' lead 42–24 followed up by Tucker's 30-yard field goal to make the score 42–27. However, the Broncos wrapped things up in the game when Peyton found D. Thomas again on a 78-yard pass to make the final score 49–27. The Ravens began their season 0–1 for the first time under John Harbaugh as head coach and Joe Flacco as their starter. They also lost their first regular season opening game since 2007 as well as becoming the 2nd straight defending Super Bowl champion team to lose their season opener.
Despite playing without star running back Ray Rice and a few other key starters, the Ravens were able to hold Houston to just 9 points despite several trips on Baltimore's side of the field, including three red zone trips. With the win, the Ravens avenging their 30-point blowout last year to Houston, improved to 2–1 overall and 7–1 all time against the Texans, including playoffs.
The Ravens were ahead 17–0 at half time, but the Bengals would then score 17 points to force overtime. At the very end of the fourth quarter, Andy Dalton threw a 51-yard Hail Mary that was first tipped by Ravens defender James Ihedigbo at the goaline, but eventually found A. J. Green in the end zone. However, about five minutes into overtime, Justin Tucker kicked the winning field goal (46 yards), and the Ravens improved to 4–5.
The game was interrupted in the first quarter, and would resume about two hours later, as a result of a torrential downpour at Soldier Field. After a slow start to the season, Ray Rice was able to rush for 131 yards and a touchdown. The Ravens were able to get the game to overtime, but the Bears would then win on a Robbie Gould field goal. The Ravens fell to 4–6.
In an eventful game, Vikings running back Adrian Peterson appeared to injure his ankle in the second quarter, and would not return to the game.
In the fourth quarter there were six lead changes, with five touchdowns scored in the final 125 seconds. Marlon Brown caught a nine-yard pass from Joe Flacco with four seconds remaining, and the Ravens improved to 7–6.
Justin Tucker scored six field goals, including a franchise record (and career long) 61-yard field goal with 38 seconds remaining in the fourth quarter. The Ravens won their fourth straight game and improved to 8–6.
With this defeat, the Ravens were eliminated from post-season contention, assuring the NFL of a new Super Bowl Champion for the ninth straight year. The Ravens finished the season with a record of 8–8. This was also the last NFL game for running back Ray Rice as he was indefinitely suspended by the NFL and released by Ravens the following season.