May 12 - Galindo Mellado Cruz, one of the founding members of the Mexican drug cartel Los Zetas, and four other armed men are killed in a shootout with Mexican security forces after they raided Cruz's hideout in the city of Reynosa.
September 26 – 6 students from the Raúl Isidro Burgos Rural Teachers College of Ayotzinapa are killed and 43 more disappear after a protest and a confrontation with Iguala, Guerrero police officers.
November 4 - Mexican Federal Police arrest a mayor and his wife, the alleged masterminds of the kidnapping of 43 students in Iguala, Guerrero.
November 7 - Parents of Mexico's missing students say authorities found 6 bags containing unidentified corpses; investigations are underway to determine if they are of the missing students. Three people confess their involvement in the massacre.
November 11 - A mob angry at the kidnapping and murder of 43 students torches the regional headquarters of Mexico's ruling Institutional Revolutionary Party (PRI) in Chilpancingo, Guerrero, and briefly holds a police commander hostage.
November 12 - Protesters attack the State Congress building in Guerrero setting alight five vehicles.