The 2017 AFC Champions League knockout stage was played from 22 May to 25 November 2017. A total of 16 teams competed in the knockout stage to decide the champions of the 2017 AFC Champions League.
In the round of 16, the winners of one group played the runners-up of another group from the same region, with the matchups determined by the group stage draw, and the group winners hosting the second leg.
The draw for the quarter-finals was held on 6 June 2017. In the quarter-finals, the four teams from the West Region played in two ties, and the four teams from the East Region played in two ties, with the matchups and order of legs decided by draw, without any seeding or country protection.
In the semi-finals, the two quarter-final winners from the West Region played each other, and the two quarter-final winners from the East Region played each other, with the order of legs determined by the quarter-final draw.
In the final, the two semi-final winners played each other, with the order of legs (first leg hosted by team from the West Region, second leg hosted by team from the East Region) reversed from the previous season's final.