Starting from the round of 16, the teams are seeded according to their results in the group stage, with the group winners (Pot 1 in round of 16 draw) seeded 1–8, and the group runners-up (Pot 2 in round of 16 draw) seeded 9–16.
In the round of 16, quarter-finals and semi-finals, each tie is played on a home-and-away two-legged basis, with the higher-seeded team hosting the second leg (Regulations Article 23). If tied on aggregate, the away goals rule will be used. If still tied, extra time will not be played, and the penalty shoot-out will be used to determine the winner (Regulations Article 29).
The final is played as a single match at a venue pre-selected by CONMEBOL, with the higher-seeded team designated as the "home" team for administrative purposes (Regulations Article 26). If tied after regulation, 30 minutes of extra time will be played. If still tied after extra time, the penalty shoot-out will be used to determine the winner (Regulations Article 30).
The draw for the round of 16 was held on 13 May 2019, 20:30 PYT (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay. For the round of 16, the 16 teams were drawn into eight ties (A–H) between a group winner (Pot 1) and a group runner-up (Pot 2), with the group winners hosting the second leg. Teams from the same association or the same group could be drawn into the same tie.