|CAF Champions League|
|CAF Confederation Cup|
|Goals scored||779 (2.05 per match)|
|Top goalscorer||Chijioke Akuneto (19 goals)|
|Biggest home win||Plateau United 5–0 Dakkada (16 January 2022)|
Akwa United 6–1 Nasarawa United (22 April 2022)
Rivers United 5–0 MFM (8 May 2022)
|Biggest away win||Heartland 0–3 Enugu Rangers (21 January 2022)|
Akwa United 0–3 Enugu Rangers (13 March 2022)
|Highest scoring||Enugu Rangers 5–3 Lobi Stars (19 March 2022)|
|Longest winning run||Plateau United (5 matches)|
|Longest unbeaten run||Rivers United (12 matches)|
|Longest winless run||Heartland & MFM (7 matches)|
|Longest losing run||Heartland , MFM & Lobi Stars (5 matches)|
2022–23 →All statistics correct as of 17 July 2022.
The 2021–22 Nigeria Professional Football League was the 51st season of Nigeria's top-flight association football league and the 32nd since attaining professionalism. The season started on 17 December 2021 and was concluded on 17 July 2022.
This season saw Shooting Stars returning to the top-flight after a four-year hiatus, likewise Niger Tornadoes who won the National League play-offs. They were also joined by Remo Stars and Gombe United after securing promotion from the second division. Akwa United were the defending champions.
On 25 June 2022, Rivers United won their first league title with 4 matches to spare.
Kano Pillars were relegated for the first time in 20 years.This occurred as a result of the team suffering a six point deduction from the league committee and the club's poor form during the season, they were joined by MFM, Heartland and Katsina United. Remo Stars secured a continental ticket for the first time in the club's history.
- Note: Several clubs played home matches at other stadiums due to their regular stadia not meeting the league requirements or being banished by the LMC.
Not including interim management.
|Team||Outgoing manager||Manner of departure||Date of departure||Incoming manager||Date of|
|Heartland||Hassan Abdallah||Resignation||2 February||Erasmus Onuh||5 February|
|Akwa United||Kennedy Boboye||Resignation||13 February||Deji Ayeni||23 March|
|Lobi Stars||Eddy Dombraye||Sacked||14 March||Mohammed Babaganaru||24 March|
|Sunshine Stars||Deji Ayeni||Left for Akwa United||23 March||Emmanuel Deutsch||2 April|
|MFM||Gabriel Olalekan||Sacked||11 May||Festus Allen||11 May|
|1||Rivers United||38||23||8||7||58||24||+34||77||Qualification for the Champions League|
|3||Remo Stars||38||18||8||12||43||26||+17||62||Qualification for the Confederation Cup|
|17||Katsina United||38||15||3||20||34||42||−8||48||Relegation to the National League|
Rules for classification: 1) points; 2) goal difference; 3) number of goals scored
Positions by round
To preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards. For example, if a match is scheduled for round 7, but then played between rounds 8 and 9, it will be added to the standings for round 8.
|Relegation to Nigeria National League|
Results by matches played
; = Win; = Draw = Loss
- As of 17 July 2022
|1||Chijioke Akuneto||Rivers United||19|
|1||Yusuf Abdulazeez||Gombe United||16|
|4||Odoh Valentine||Abia Warriors||15|
|5||Ishaq Rafiu||Rivers United||14|
|6||Andy Okpe||Remo Stars||13|
|7||Godwin Obaje||Abia Warriors||12|
|8||Zulkifilu Rabiu||Plateau United||11|
|Tochukwu Udeh||Nasarawa United|
|10||Samad Kadiri||Kwara United||10|
|Ossy Martins||Enugu Rangers|
|Leonard Ugochukwu||Sunshine Stars|
|Chijioke Akuneto||Rivers United||Akwa United||4–1 (H)||20 March 2022|
|Victor Mbaoma||Enyimba||Kwara United||3–0 (H)||12 June 2022|
|Andy Okpe||Remo Stars||Niger Tornadoes||3–0 (H)||17 July 2022|
(H) – Home team
- "NPFL 2021–22 season starts December 17". The Nation. 25 November 2021.
- Oludare, Shina (12 September 2021). "3SC, Remo Stars, Niger Tornadoes and Gombe United promoted to NPFL". Goal. Retrieved 25 November 2021.
- "Rivers United NPFL title win thrills Wike". The Punch. 27 June 2022.
- "Kano Pillars four time NPFL kings relegated after losing appeal against Dakkada". Goal.com. 16 July 2022.
- "DECISION OF THE NFF DISCIPLINARY COMMITTEE MEETING HELD ON JULY 8, 2022". Sportsration. 9 July 2022.
- "Kano Pillars hit with hefty fine, points deduction". brila.net. 17 April 2022.
- "NPFL round up:Remo Stars punch continental ticket as Andy Okpe scores hattrick". Premium Times. 17 July 2022.
- "Onuh replaces Abdallah as Heartland coach". Dailypost.ng. 6 February 2022.
- "NPFL:Kennedy Boboye quits Akwa United". Premiumtimesng.com. 14 February 2022. Retrieved 4 March 2022.
- "MFM set to announce Festus Allen as technical adviser". Exclusive News. 11 May 2022.
- "Kwara United pick Confederation Cup slot ahead of Aiteo Cup finals". Premium Times Nigeria. 8 August 2022. Retrieved 22 May 2023.
- "Niger Tornadoes fined 2 million with two points deduction for breach of NPFL framework and rules". The News Chronicle. 9 June 2022.
- "NPFL Review:Akuneto scores hattrick as Rivers United finish midseason champions". 20 March 2022.
- "Mbaoma breaks Enyimba 9-year record with hattrick". blueprint.ng. 12 June 2022.