Year 216 BC was a year of the pre-Julian Roman calendar. At the time it was known as the Year of the Consulship of Varro and Paullus (or, less frequently, year 538 Ab urbe condita). The denomination 216 BC for this year has been used since the early medieval period, when the Anno Dominicalendar era became the prevalent method in Europe for naming years.
Philip V of Macedon, still resenting Rome's interference in Illyrian politics, seizes his opportunity to invade Illyria. Ambassadors from Philip V visit Hannibal at his headquarters in Italy. These actions mark the beginning of the First Macedonian War between Rome and Macedonia.