22 may refer to:
Art, entertainment, and media
- 22 (album), an album by Parva
- "22" (Lily Allen song), from Lily Allen's second studio album, It's Not Me, It's You
- "22" (Taylor Swift song), from Taylor Swift's fourth studio album, Red
- "22", a song by Gavin James from his 2016 album Bitter Pill
- "Twenty Two" (Millencolin song), a song by Millencolin
- Highway 22 or Route 22
- Massachusetts Bay Transportation Authority bus route 22
- New Jersey Transit bus route 22
Help the earth (April 22) see earth day
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