23S rRNA pseudouridine746 synthase

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23S rRNA pseudouridine746 synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

23S rRNA pseudouridine746 synthase (EC, RluA, 23S RNA PSI746 synthase, 23S rRNA pseudouridine synthase, pseudouridine synthase RluA) is an enzyme with systematic name 23S rRNA-uridine746 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine746 23S rRNA pseudouridine746

RluA is the only protein responsible for the in vivo formation of 23S RNA pseudouridine746.


  1. ^ Hoang, C.; Chen, J.; Vizthum, C.A.; Kandel, J.M.; Hamilton, C.S.; Mueller, E.G.; Ferre-D'Amare, A.R. (2006). "Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure". Mol. Cell. 24: 535–545. doi:10.1016/j.molcel.2006.09.017. PMID 17188032. 
  2. ^ Raychaudhuri, S.; Niu, L.; Conrad, J.; Lane, B.G.; Ofengand, J. (1999). "Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA". J. Biol. Chem. 274: 18880–18886. doi:10.1074/jbc.274.27.18880. PMID 10383384. 
  3. ^ Wrzesinski, J.; Nurse, K.; Bakin, A.; Lane, B.G.; Ofengand, J. (1995). "A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for Ψ746 in 23S RNA is also specific for Ψ32 in tRNAPhe". RNA. 1: 437–448. PMC 1482406Freely accessible. PMID 7493321. 

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