23S ribosomal RNA

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Pseudoknot of the domain G(G12) of 23S ribosomal RNA
PK-G12rRNA secondary structure.jpg
Predicted secondary structure and sequence conservation of PK-G12rRNA
Symbol PK-G12rRNA
Rfam RF01118
Other data
RNA type Gene; rRNA
Domain(s) Bacteria
SO 0001263
A 3D representation of the ribosome. This is a view of the 3D arrangement of the 23S and 5S rRNA in the Escherichia coli 50S ribosomal subunit based on a cryo-electron microscopic reconstruction.[1]
A 3D representation of the ribosome.[2]

The 23S rRNA is a 2904 nt long (in E. coli) component of the large subunit (50S) of the bacterial ribosome. The ribosomal peptidyl transferase activity resides in domain V of this rRNA, and this domain is the most common binding site for antibiotics that inhibit translation. A well-known member of this antibiotic class, Chloramphenicol, acts by inhibiting peptide bond formation, with recent 3D-structural studies showing two different binding sites depending on the species of ribosome. Linezolid and quinupristin-dalfopristin also bind to the 23S rRNA, and cross-resistance has been demonstrated between these antibiotics.[citation needed]

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  1. ^ Mueller F, Sommer I, Baranov P, Matadeen R, Stoldt M, Wöhnert J, Görlach M, van Heel M, Brimacombe R (2000). "The 3D arrangement of the 23 S and 5 S rRNA in the Escherichia coli 50 S ribosomal subunit based on a cryo-electron microscopic reconstruction at 7.5 A resolution.". J Mol Biol 298 (1): 35–59. doi:10.1006/jmbi.2000.3635. PMID 10756104. 
  2. ^ Halic M, Blau M, Becker T, Mielke T, Pool MR, Wild K, Sinning I, Beckmann R (2006). "Following the signal sequence from ribosomal tunnel exit to signal recognition particle.". Nature 444 (7118): 507–11. doi:10.1038/nature05326. PMID 17086193. 

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