Year 253 BC was a year of the pre-Julian Roman calendar. At the time it was known as the Year of the Consulship of Caepio and Blaesus (or, less frequently, year 501 Ab urbe condita). The denomination 253 BC for this year has been used since the early medieval period, when the Anno Dominicalendar era became the prevalent method in Europe for naming years.
The war is concluded with the marriage of Antiochus to Ptolemy II's daughter, Berenice Syra. Antiochus divorces his previous wife, Laodice, and transfers the succession to Berenice's children.
In recapturing the city of Miletus, Antiochus II overthrows the tyrant of the city. In response, the citizens worship him as a god in thanksgiving leading to the addition of Theos to Antiochus II's name.
Alexander, Antigonus II's nephew and regent, leads a revolt in Corinth with Ptolemy II's help and declares himself an independent monarch. As a result, Antigonus loses Corinth and Chalcis, the two bases from which he has dominated southern Greece. As the Aetolians occupy Thermopylae, Antigonus II is cut off from Athens and the Peloponnese.
Macedonia's involvement in the second Syrian War ceases when Antigonus becomes preoccupied with the rebellion of Corinth and Chalcis, as well as an increase in enemy activity along Macedon's northern frontier.