25B-NBOH ( 2C-B-NBOH, NBOH-2C-B) is a derivative of the phenethylamine derived hallucinogen 2C-B which has been sold as a designer drug. It acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25B-NBOMe at 5-HT and 2A 5-HT receptors with pK 2C is values of 8.3 and 9.4, respectively.     
Legal status [ edit ]
The Riksdag added 25B-NBOH to Narcotic Drugs Punishments Act under swedish schedule I ( "substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 25B-NBOH, and 2-([2-(4-bromo-2,5-dimetoxifenyl)etylamino]metyl)fenol.
United Kingdom [ edit ]
This substance is a Class A drug in the United Kingdom as a result of the
N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.
Analogues and derivatives [ edit ]
References [ edit ]
Heim, Ralf (19 March 2004). "Synthese und Pharmakologie potenter 5-HT. Freie Universität Berlin 2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur" . Retrieved . 27 June 2015
Hansen, M.; Phonekeo, K.; Paine, J. S.; Leth-Petersen, S.; Begtrup, M.; Bräuner-Osborne, H.; Kristensen, J. L. (2014). "Synthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT. 2A/2C Agonists" ACS Chemical Neuroscience. 5 (3): 243–9. doi: 10.1021/cn400216u. PMC . 3963123 PMID 24397362.
Martin Hansen (2011). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain" (PDF). University of Copenhagen . Retrieved . 27 June 2015
Ettrup, A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M.; Madsen, J. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT 2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681–693. doi: 10.1007/s00259-010-1686-8. PMID 21174090.
Silva, M. E.; Heim, R.; Strasser, A.; Elz, S.; Dove, S. (2011). "Theoretical studies on the interaction of partial agonists with the 5-HT 2A receptor". Journal of Computer-aided Molecular Design. 25 (1): 51–66. doi: 10.1007/s10822-010-9400-2. PMID 21088982.
Braden, M. R.; Parrish, J. C.; Naylor, J. C.; Nichols, D. E. (2006). "Molecular interaction of serotonin 5-HT2A receptor residues Phe. 339 6.51 and Phe 340 6.52 with superpotent N-benzyl phenethylamine agonists" Molecular Pharmacology. 70 (6): 1956–1964. doi: 10.1124/mol.106.028720. PMID 17000863.
"The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". www.legislation.gov.uk.