25B-NBOH ( 2C-B-NBOH, NBOH-2C-B) is a derivative of the phenethylamine derived hallucinogen 2C-B which has been sold as a designer drug. It acts as a potent serotonin receptor agonist with similar affinity to the better-known compound 25B-NBOMe at 5-HT and 2A 5-HT receptors with pK 2C is values of 8.3 and 9.4, respectively.     
Legal status [ edit ]
The Riksdag added 25B-NBOH to Narcotic Drugs Punishments Act under swedish schedule I ( "substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 25B-NBOH, and 2-([2-(4-bromo-2,5-dimetoxifenyl)etylamino]metyl)fenol.
United Kingdom [ edit ]
This substance is a Class A drug in the United Kingdom as a result of the
N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.
Analogues and derivatives [ edit ]
References [ edit ]
Heim, Ralf (19 March 2004). "Synthese und Pharmakologie potenter 5-HT. Freie Universität Berlin 2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur" . Retrieved . 27 June 2015
Hansen, M.; Phonekeo, K.; Paine, J. S.; Leth-Petersen, S.; Begtrup, M.; Bräuner-Osborne, H.; Kristensen, J. L. (2014). "Synthesis and Structure-Activity Relationships of N-Benzyl Phenethylamines as 5-HT. 2A/2C Agonists" ACS Chemical Neuroscience. 5 (3): 243–9. doi: 10.1021/cn400216u. PMC . 3963123 PMID 24397362.
Martin Hansen (2011). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain" (PDF). University of Copenhagen. Archived from the original (PDF) on 4 July 2015 . Retrieved . 27 June 2015
Ettrup, A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M.; Madsen, J. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT 2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681–693. doi: 10.1007/s00259-010-1686-8. PMID 21174090.
Silva, M. E.; Heim, R.; Strasser, A.; Elz, S.; Dove, S. (2011). "Theoretical studies on the interaction of partial agonists with the 5-HT 2A receptor". Journal of Computer-aided Molecular Design. 25 (1): 51–66. CiteSeerX . 10.1.1.688.2670 doi: 10.1007/s10822-010-9400-2. PMID 21088982.
Braden, M. R.; Parrish, J. C.; Naylor, J. C.; Nichols, D. E. (2006). "Molecular interaction of serotonin 5-HT2A receptor residues Phe. 339 6.51 and Phe 340 6.52 with superpotent N-benzyl phenethylamine agonists" Molecular Pharmacology. 70 (6): 1956–1964. doi: 10.1124/mol.106.028720. PMID 17000863.
"The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". www.legislation.gov.uk.