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2A or II-A may refer to:
- Alberta Highway 2A
- Alpha-2A adrenergic receptor
- Keratin 2A
- Massachusetts Route 2A
- Stalag II-A
- Telecom 2A, a satellite
- the Transcription Factor II A
- the Deutsche Bahn IATA designator
- Second Amendment of various constitutions
- the Second Amendment to the United States Constitution that protects right to keep and bear arms
- the number of the French department Corse-du-Sud
- a strain of the bacterium Lactobacillus sakei
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