2P may refer to:
- 2P/Encke, official designation of Comet Encke
- 2p, an arm of Chromosome 2 (human)
- 2p, an atomic orbital for electrons
- 2P, a 406mm artillery piece from the Soviet Union
- 2p, two pence (British decimal coin)
- 2P, rapper 2 Pistols
- 2P reserves of fossil fuels
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