|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||302.196 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
3,4-Dichloromethylphenidate (or 3,4-DCMP) is a stimulant drug related to methylphenidate. Dichloromethylphenidate is a potent psychostimulant that acts as both a dopamine reuptake inhibitor and norepinephrine reuptake inhibitor, meaning it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain, by binding to, and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft.
3,4-DCMP, the threo-diastereomer, is approximately seven times more potent than methylphenidate in animal studies, but has weaker reinforcing effects due to its slower onset of action. However, H. M. Deutsch's discrimination ratio[clarification needed] implies it to be more reinforcing than cocaine.
As of October 2015 3,4-CTMP is a controlled substance in China.
Sweden's public health agency suggested to classify 3,4-CTMP as hazardous substance on 10 November 2014.
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- Wayment, HK; Deutsch, H; Schweri, MM; Schenk, JO (1999). "Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists?". Journal of Neurochemistry. 72 (3): 1266–74. doi:10.1046/j.1471-4159.1999.0721266.x. PMID 10037500.
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- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- Methylphenidate-based NPS: A review of the evidence of use and harm. Advisory Council on the Misuse of Drugs, 31 March 2015
- "Cannabinoider föreslås bli klassade som hälsofarlig vara". Retrieved 29 June 2015.