3-Aminopyridine

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3-Aminopyridine
3-aminopyridine.svg
Names
IUPAC name
Pyridin-3-amine
Other names
3-Pyridinamine; 3-Pyridylamine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.006.658
Properties
C5H6N2
Molar mass 94.117 g·mol−1
Appearance [citation needed]
Melting point 65 °C (149 °F; 338 K)
Boiling point 248 °C (478 °F; 521 K)
Soluble[vague]
Solubility in alcohol and benzene Soluble[vague]
Hazards
Flash point 124 °C (255 °F; 397 K)
628 °C (1,162 °F; 901 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

3-Aminopyridine is an aminopyridine. It is a colorless solid.[1]

Preparation[edit]

3-Aminopyridine is prepared by heating nicotinamide with sodium hypobromite which is in turn prepared in situ by the reaction of sodium hydroxide and bromine at 70 °C.[2]

Synthesis of 3-Aminopyridine.gif

It can be used in the synthesis of organic ligand 3-pyridylnicotinamide.

Toxicity[edit]

The acute toxicity is indicated by the LD50 = 178 mg/kg (quail, oral).[1]

References[edit]

  1. ^ a b Shinkichi Shimizu, Nanao Watanabe, Toshiaki Kataoka, Takayuki Shoji, Nobuyuki Abe, Sinji Morishita, Hisao Ichimura (2000), "Pyridine and Pyridine Derivatives", Ullmann's Encyclopedia of Industrial Chemistry, Weinheim: Wiley-VCH, doi:10.1002/14356007.a22_399CS1 maint: Uses authors parameter (link)
  2. ^ Allen, C. F. H.; Wolf, Calvin N. (1950). "3-Aminopyridine". Organic Syntheses. 30: 3. doi:10.15227/orgsyn.030.0003.; Collective Volume, 4, p. 45