3-Hydroxybutyrate dehydrogenase

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3-Hydroxybutyrate dehydrogenase
EC no.
CAS no.9028-38-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, 3-hydroxybutyrate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction:

(R)-3-hydroxybutanoate + NAD+ acetoacetate + NADH + H+

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD+, whereas its three products are acetoacetate, NADH, and H+. This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

This enzyme participates in the synthesis and degradation of ketone bodies and the metabolism of butyric acid.


The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD+ oxidoreductase. Other names in common use include:

  • NAD+-β-hydroxybutyrate dehydrogenase
  • hydroxybutyrate oxidoreductase
  • β-hydroxybutyrate dehydrogenase
  • D-β-hydroxybutyrate dehydrogenase
  • D-3-hydroxybutyrate dehydrogenase
  • D-(–)-3-hydroxybutyrate dehydrogenase
  • β-hydroxybutyric acid dehydrogenase
  • 3-D-hydroxybutyrate dehydrogenase
  • β-hydroxybutyric dehydrogenase

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.

See also[edit]


  • Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH (1967). "Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides". Biochem. J. 102 (2): 423–31. doi:10.1042/bj1020423. PMC 1270263. PMID 4291491.
  • Delafield FP, Cooksey KE, Doudoroff M (1965). "beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei". J. Biol. Chem. 240 (10): 4023–8. PMID 4954074.
  • Lehninger AL, Sudduth HC, Wise JB (1960). "D-beta-Hydroxybutyric dehydrogenase of mitochondria". J. Biol. Chem. 235: 2450–2455. PMID 14415394.