3-Iodotyrosine

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3-Iodotyrosine
Skeletal formula of 3-iodotyrosine
Ball-and-stick model of the 3-iodotyrosine molecule as a zwitterion
Identifiers
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
ChEBI
ChEMBL
Chemical and physical data
Formula C9H10INO3
Molar mass 307.09 g/mol
3D model (JSmol)
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3-Iodotyrosine is a reversible inhibitor of the enzyme tyrosine hydroxylase.[1] It is an intermediate peptide in the synthesis of thyroid hormones.

Relevance in Dopamine Studies[edit]

 3-iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitter dopamine, was used to determine the effects of decreased dopamine levels in social spacing of Drosophila melanogaster. 3-4 day old flies that were fed 3-Iodotyrosine for 24 hours were shown to have altered dopamine levels.[2]

References[edit]

  1. ^ Richelson E (November 1976). "Properties of tyrosine hydroxylation in living mouse neuroblastoma clone N1E-115". Journal of Neurochemistry. 27 (5): 1113–8. PMID 12170597. doi:10.1111/j.1471-4159.1976.tb00317.x. 
  2. ^ Fernandez, Robert W.; Akinleye, Adesanya A.; Nurilov, Marat; Feliciano, Omar; Lollar, Matthew; Aijuri, Rami R.; O'Donnell, Janis M.; Simon, Anne F. (2017-08-01). "Modulation of social space by dopamine in Drosophila melanogaster, but no effect on the avoidance of the Drosophila stress odorant". Biology Letters. 13 (8): 20170369. ISSN 1744-9561. doi:10.1098/rsbl.2017.0369.