3-dehydro-L-gulonate 2-dehydrogenase dimer, E.Coli
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- 3-dehydro-L-gulonate + NAD(P)+ (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.
- Volk WA, Larsen JL (1962). "beta-Keto-L-gulonic acid as an intermediate in the bacterial metabolism of ascorbic acid". J. Biol. Chem. 237: 2454–7. PMID 13926592.
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