|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- 3-hydroxy-2-methylpropanoyl-CoA + H2O CoA + 3-hydroxy-2-methylpropanoate
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism. 3-hydroxyisobutyryl-CoA hydrolase is encoded by HIBCH gene.
- "OMIM Entry - * 610690 - 3-HYDROXYISOBUTYRYL-CoA HYDROLASE; HIBCH". www.omim.org. Retrieved 2017-11-20.
- Rendina G, Coon MJ (March 1957). "Enzymatic hydrolysis of the coenzyme a thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". The Journal of Biological Chemistry. 225 (1): 523–34. PMID 13457352.