3-mercaptopyruvate sulfurtransferase

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3-mercaptopyruvate sulfurtransferase
Identifiers
EC number 2.8.1.2
CAS number 9026-05-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) is an enzyme that catalyzes the chemical reaction

3-mercaptopyruvate + cyanide pyruvate + thiocyanate
3-mercaptopyruvate + thiol pyruvate + hydrogen sulfide

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3-mercaptopyruvate:cyanide sulfurtransferase. This enzyme is also called beta-mercaptopyruvate sulfurtransferase. This enzyme participates in cysteine metabolism.

Structural studies[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1OKG and 1URH.

References[edit]

  • Fiedler H; Wood JL (1956). "Specificity studies on the beta-mercaptopyruvate-cyanide transsulfuration system". J. Biol. Chem. 222 (1): 387–397. PMID 13367011. 
  • HYLIN JW; WOOD JL (1959). "Enzymatic formation of polysulfides from mercaptopyruvate". J. Biol. Chem. 234 (8): 2141–4. PMID 13673028. 
  • Sorbo BH (1957). "Enzymic transfer of sulfur from mercaptopyruvate to sulfite or sulfinates". Biochem. Biophys. Acta. 24: 324–329. doi:10.1016/0006-3002(57)90201-9. 
  • Vachek H; Wood JL (1972). "Purification and properties of mercaptopyruvate sulfur transferase of Escherichia coli". Biochim. Biophys. Acta. 258 (1): 133–46. PMID 4550801. doi:10.1016/0005-2744(72)90973-4. 
  • Van den Hamer CJ; Morell AG; Scheinberg IH (1967). "A study of the cooper content of beta-mercaptopyruvate trans-sulfurase". J. Biol. Chem. 242 (10): 2514–6. PMID 6026243.