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Systematic (IUPAC) name
Clinical data
Legal status
CAS Registry Number 86052-04-2
PubChem CID: 62296
DrugBank DB01439 YesY
ChemSpider 56092 YesY
ChEBI CHEBI:53763 YesY
Synonyms N-[3-methyl-1-(2-thiophen-2-ylethyl)-4-piperidyl]-N-phenyl-propanamide; 3-methyl-thiofentanyl
Chemical data
Formula C21H28N2OS
Molecular mass 356.526 g/mol
 YesY (what is this?)  (verify)

3-Methyl-thiofentanyl is an opioid analgesic and analogue of fentanyl.

3-Methyl-thiofentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.[1]

3-Methyl-thiofentanyl has similar effects to fentanyl. Side effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression which can be life-threatening.

See also[edit]


  1. ^ Henderson GL. Designer Drugs: Past History and Future Prospects. Journal of Forensic Sciences 1988; 33(2):569-575.
  2. ^ Mićović, I. V.; Ivanović, M. D.; Vuckovic, S. M.; Prostran, M. Š.; Došen-Mićović, L.; Kiricojević, V. D. (2000). "The Synthesis and preliminary pharmacological evaluation of 4-Methyl fentanyl". Bioorganic & Medicinal Chemistry Letters 10 (17): 2011. doi:10.1016/S0960-894X(00)00394-2.