30S

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Atomic structure of the 30S Subunit from Thermus thermophilus. Proteins are shown in blue and the single RNA strand in orange.[1]

30S is the smaller subunit of the 70S ribosome found in prokaryotes. It is a complex of the 16S ribosomal RNA and 22 ribonucleoproteins. It complexes with the larger 50S subunit to form the 70S prokaryotic ribosome in the cell.

Function[edit]

30S subunit is an integral part of mRNA translation. It binds three Prokaryotic initiation factors: IF-1, IF-2, and IF-3. In addition, a portion of the 30S subunit (the 16S rRNA) guides the initiating (5')-AUG codon of the mRNA into place by lining up a complementary sequence of RNA on the 16S subunit with the Shine-Dalgarno sequence on the mRNA. This ensures the ribosome starts translation at the correct location.

Inhibition[edit]

The 30S subunit is the site of inhibition for the tetracycline and aminoglycoside antibiotics

See also[edit]

References[edit]

  1. ^ Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A (2000). "Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution". Cell. 102 (5): 615–23. doi:10.1016/S0092-8674(00)00084-2. PMID 11007480. 

External links[edit]