4-Androstenediol

From Wikipedia, the free encyclopedia
Jump to: navigation, search
4-Androstenediol
4-Androstenediol.svg
4-Androstenediol3D.png
Clinical data
Synonyms Androst-4-ene-3β,17β-diol
Routes of
administration
Oral
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
ChEMBL
Chemical and physical data
Formula C19H30O2
Molar mass 290.44 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

4-Androstenediol, also known as androst-4-ene-3β,17β-diol, is an androstenediol that is converted to testosterone. The conversion rate is about 15.76%, almost triple that of 4-androstenedione, due to utilization of a different enzymatic pathway. There is also some conversion into estrogen, since testosterone is the metabolic precursor of the estrogens.

4-Androstenediol is closer to testosterone structurally than 5-androstenediol, and has androgenic effects, acting as a weak partial agonist of the androgen receptor.[1] However, due to its lower intrinsic activity in comparison, in the presence of full agonists like testosterone or dihydrotestosterone (DHT), 4-androstenediol has antagonistic actions, behaving more like an antiandrogen.[1]

4-Androstenediol is very weakly estrogenic. It has approximately 0.5% and 0.6% of the affinity of estradiol at the ERα and ERβ, respectively.[2]

Medical and commercial use[edit]

Patrick Arnold holds a 1999 patent on "Use of 4-androstenediol to increase testosterone levels in humans".[3]

References[edit]

  1. ^ a b Chen F, Knecht K, Leu C, et al. (August 2004). "Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol". The Journal of Steroid Biochemistry and Molecular Biology. 91 (4-5): 247–57. PMID 15336702. doi:10.1016/j.jsbmb.2004.04.009. 
  2. ^ Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA (1997). "Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta". Endocrinology. 138 (3): 863–70. PMID 9048584. doi:10.1210/endo.138.3.4979. 
  3. ^ http://www.patentstorm.us/patents/5880117/description.html