|Chemical and physical data|
|Molar mass||368.496 g·mol−1|
|3D model (JSmol)|
4-Fluoroisobutyrylfentanyl (also known as 4-FIBF and p-FIBF) is an opioid analgesic that is an analog of butyrfentanyl and structural isomer of 4-Fluorobutyrfentanyl and has been sold online as a designer drug. It is closely related to 4-fluorofentanyl, which has an EC50 value of 4.2 nM for the human μ-opioid receptor.
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.
- List of fentanyl analogues
- "FIBF". Cayman Chemical.
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- Ulens, Chris; Boven, Maurits Van; Daenens, Paul; Tytgat, Jan (1 September 2000). "Interaction of p-Fluorofentanyl on Cloned Human Opioid Receptors and Exploration of the Role of Trp-318 and His-319 in μ-Opioid Receptor Selectivity". Journal of Pharmacology and Experimental Therapeutics. 294 (3): 1024–1033. ISSN 1521-0103. PMID 10945855.
- Mounteney, Jane; Giraudon, Isabelle; Denissov, Gleb; Griffiths, Paul (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe". International Journal of Drug Policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.
- "Controlled Substances by DEA Drug Code Number" (PDF). Drug Enforcement Agency.