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4-chlorophenylacetate 3,4-dioxygenase

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4-chlorophenylacetate 3,4-dioxygenase
Identifiers
EC no.1.14.12.9
CAS no.105006-00-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a 4-chlorophenylacetate 3,4-dioxygenase (EC 1.14.12.9) is an enzyme that catalyzes the chemical reaction

4-chlorophenylacetate + NADH + H+ + O2 3,4-dihydroxyphenylacetate + chloride + NAD+

The 4 substrates of this enzyme are 4-chlorophenylacetate, NADH, H+, and O2, whereas its 3 products are 3,4-dihydroxyphenylacetate, chloride, and NAD+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is 4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating). It employs one cofactor, iron.

References

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  • Markus A, Krekel D, Lingens F (1986). "Purification and some properties of component A of the 4-chlorophenylacetate 3,4-dioxygenase from Pseudomonas species strain CBS". J. Biol. Chem. 261 (27): 12883–8. PMID 3745216.