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Acetanisole V.1.svg
Preferred IUPAC name
Other names
4-Acetylanisole; para-Acetanisole; 4-Methoxyacetophenone; Linarodin; Novatone; Vananote; Castoreum anisole; 4-Methoxyphenyl methyl ketone
100-06-1 YesY
ChemSpider 7196 YesY
ECHA InfoCard 100.002.560
Jmol 3D model Interactive image
PubChem 7476
Molar mass 150.18 g·mol−1
Appearance White to pale yellow crystals[1]
Density 1.094 g/cm3
Melting point 38.5 °C (101.3 °F; 311.6 K)[2]
Boiling point 258 °C (496 °F; 531 K)[2]
2470 mg/L[2]
Flash point 138 °C (280 °F)[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Acetanisole is an aromatic chemical compound with an aroma described as sweet, fruity, nutty, and similar to vanilla. In addition Acetanisole can sometimes smell like butter or caramel. [3]

Acetanisole is found naturally in castoreum, the glandular secretion of the beaver.[1]


Acetanisole can be prepared synthetically by Friedel-Crafts acylation of anisole with acetyl chloride:

Acetanisol Synthesis.svg


It is used as a cigarette additive,[4] a fragrance,[1] and a flavoring in food.[5]

  1. In the pharmaceutical sector, acetanisole is used in the synthesis of Benfurodil hemisuccinate.[6]
  2. It can also be used to synthesize basic stimulant compounds such as methyl-synephrine and methyl-hordenine, which were detected in the energy supplement Meltdown®.[7]
  3. In the case of m-acetanisole, this regioisomer was used to synthesize oxyfedrine.


At room temperature 4-Methoxyacetophenone is solid, and has a white crystal like structure. Once melted, the white crystals turn into a clear liquid.


  1. ^ a b c Para-Acetanisole, The Good Scents Company
  2. ^ a b c Acetanisole in the ChemIDplus database
  3. ^ a b Acetanisole at Sigma-Aldrich
  4. ^ Tobacco Documents | Profiles | Additives | Acetanisole Archived April 11, 2008, at the Wayback Machine.
  5. ^ 21 C.F.R. 172.515
  6. ^
  7. ^ Hoffman, Jay R; Kang, Jie; Ratamess, Nicholas A; Rashti, Stefanie L; Tranchina, Christopher P; Faigenbaum, Avery D (2009). "Thermogenic effect of an acute ingestion of a weight loss supplement". Journal of the International Society of Sports Nutrition. 6 (1): 1. doi:10.1186/1550-2783-6-1. ISSN 1550-2783.