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45s or 45S may refer to:
- Silver Lake Forest Service Strip's FAA identifier
- Forty-fives, a trick-taking card game
- 45s: 45 rpm 7" vinyl single records spun at forty-five revolutions per minute (rpm or RPM); some Gramophone records also spun at 45 rpm.
- FourFiveSeconds, a song by Rihanna, Kanye West and Paul McCartney
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