Valentino Rossi, one of the most successful motorcycle riders of all time, uses 46 as his number in the MotoGP motorcycle world championship, and has been using this number in homage to his father since he started racing as a youngster.
46 is the number that unlocks the Destiny spaceship on the popular Sci-Fi TV show Stargate Universe. Dr. Rush discovers that the number 46 relates to the amount of human chromosomes and begins sequencing different genetic codes to finally gain control of the ship's operating system. The episode was called "Humans".
The number depicted in the first flag of Oklahoma (replaced in 1925), signifying the fact that Oklahoma was the 46th state to join the United States.
^Barbara J. Trask, "Human genetics and disease: Human cytogenetics: 46 chromosomes, 46 years and counting" Nature Reviews Genetics3 (2002): 769. "Human cytogenetics was born in 1956 with the fundamental, but empowering, discovery that normal human cells contain 46 chromosomes."