4a-hydroxytetrahydrobiopterin dehydratase

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4-alpha-hydroxytetrahydrobiopterin dehydratase
Identifiers
EC number 4.2.1.96
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96) is an enzyme that catalyzes the chemical reaction

(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a- hydroxypterin (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O

Thus, the two substrates of this enzyme are (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a- and hydroxypterin, whereas its two products are (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxy pterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-formin g]. Other names in common use include 4alpha-hydroxy-tetrahydropterin dehydratase, pterin-4alpha-carbinolamine dehydratase, and 4a-hydroxytetrahydrobiopterin hydro-lyase.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DCO, 1DCP, and 1RU0.

References[edit]

  • Blau N, Ghisla S, Heizmann CW (1993). "Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver Purification, characterization, and complete amino acid sequence". J. Biol. Chem. 268 (7): 4828–31. PMID 8444860.