GppNHp; GppNP; GMP-Pnp; GDP-NP
3D model (JSmol)
|Molar mass||g·mol−1 522.196|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
5'-Guanylyl imidodiphosphate is a purine nucleotide. It is an analog of guanosine triphosphate in which one of the oxygen atoms is replaced with an amine, producing a non-hydrolyzable functional group. Guanylyl imidodiphosphate binds tightly to G-proteins in the presence of Mg2+. Guanylyl imidodiphosphate is a potent stimulator of adenylate cyclase. It is often used in studies of protein synthesis.
- Guanosine 5′-β,γ-imidotriphosphate trisodium salt hydrate at Sigma-Aldrich
- Guanylyl imidodiphosphate at PubChem
- Miller, J.D. & Walter, P. (1993). "A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane". Ciba Found. Symp. 176: 147–163. PMID 8299417.
- Connolly, T.; et al. (1991). "Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor". Science. 252 (5009): 1171–1173. doi:10.1126/science.252.5009.1171. PMID 1851576.