Hydrallostane; 11β,17α,21-Trihydroxy-5α-pregnane-3,20-dione; 5α-DHF; Allodihydrocortisol
3D model (JSmol)
|Molar mass||364.482 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
5α-Dihydrocortisol (5α-DHF), also known as hydrallostane or as allodihydrocortisol, is a metabolite of cortisol that is formed by 5α-reductase. It is present in the aqueous humor of the eye, is produced in the lens of the eye, and be involved in regulating the formation of the aqueous humor. 5α-DHF can be further metabolized into 3α,5α-tetrahydrocortisol by 3α-hydroxysteroid dehydrogenase.
- Azzouni F, Godoy A, Li Y, Mohler J (2012). "The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases". Adv Urol. 2012: 530121. doi:10.1155/2012/530121. PMC 3253436. PMID 22235201.
- Wilson JD (2001). "The role of 5alpha-reduction in steroid hormone physiology". Reprod. Fertil. Dev. 13 (7–8): 673–8. doi:10.1071/RD01074. PMID 11999320.
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