S,8 R,9 S,10 S,13 S,14 S,17 S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[ a]phenanthren-3-one
Jmol 3D model
21H 32O 2
Molar mass 316.48 g/mol
Except where otherwise noted, data are given for materials in their
(at 25 °C [77 °F], 100 kPa).
5α-Dihydroprogesterone ( 5α-DHP), also known as 5α-pregnan-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.  It is also an  intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone. 5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABA (albeit with an A receptor affinity for this receptor that is regarded as relatively low (in comparison to 3α-hydroxylated progesterone metabolites such as allopregnanolone and pregnanolone)).    It has also been found to act as a  negative allosteric modulator of the GABA. A-rho receptor In addition, it is a weak agonist of the  pregnane X receptor (PXR) ( EC >10,000 µM)), with approximately six-fold lower potency relative to its 5β-isomer, 50 5β-dihydroprogesterone. 
See also [ edit ]
References [ edit ]
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