5,7-Dihydroxytryptamine

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5,7-Dihydroxytryptamine
5,7-Dihydroxytryptamine.svg
Names
IUPAC name
3-(2-aminoethyl)-1H-indole-5,7-diol
Other names
5,7-Dihydroxytryptamine
Identifiers
3D model (Jmol)
ChemSpider
ECHA InfoCard 100.045.977
Properties
C10H12N2O2
Molar mass 192.214 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

5,7-Dihydroxytryptamine (5,7-DHT) is a purported neurotoxin[1][2] used in scientific research to decrease concentrations of serotonin in the brain. The mechanism behind this effect isn't well-understood, but many believe (without clear substantiation) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine (6-OHDA) is used to kill dopaminergic cells. What is known is that this compound is in fact not selective in depleting serotonin content, but also depletes norepinephrine. To selectively deplete serotonin stores, it is commonly administered in conjunction with desmethylimiprimine (desipramine)[3], which inhibits the norepinephrine transporter.

See also[edit]

References[edit]

  1. ^ Cairncross, KD; Cox, B; Forster, C; Wren, A (1977). "The ability of local injection of 6-OHDA, 5,6-DHT and 5,7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat proceedings". British Journal of Pharmacology. 61 (1): 145P–146P. doi:10.1111/j.1476-5381.1977.tb09748.x. PMC 1667625Freely accessible. PMID 912193. 
  2. ^ Liu, J; Chu, YX; Zhang, QJ; Wang, S; Feng, J; Li, Q (2007). "5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus alters neuronal activity of the subthalamic nucleus in normal and 6-hydroxydopamine-lesioned rats". Brain Research. 1149: 216–22. doi:10.1016/j.brainres.2007.02.052. PMID 17376410. 

3. Martin-Iverson, M.T., Leclere, J.F. and Fibiger, H.C., Cholinergic-dopaminergic interactions and the mechanisms of action of antidepressants, European Journal of Pharmacology, 94 (1983) 193-201.