5-(2-Aminopropyl)-2,3-dihydro-1 ( H-indene 5-APDI), also known as indanylaminopropane ( IAP), IAP (psychedelic), 2-API(2-aminopropylindane), indanametamine, and, incorrectly, as indanylamphetamine, is an [1 ] entactogen and psychedelic drug of the amphetamine family. [2 ] It has been sold by [3 ] online vendors through the Internet and has been encountered as a designer drug since 2003, but its popularity and availability has diminished in recent years. [1 ]
5-APDI acts as a
potent and weakly selective serotonin releasing agent (SSRA) with IC values of 82 nM, 1,848 nM, and 849 nM for inhibiting the 50 reuptake of serotonin, dopamine, and norepinephrine, respectively. [2 ] It fully substitutes for [3 ] MBDB but not amphetamine in trained animals, though it does produce disruption for the latter at high doses. [2 ]
5-ADPI has been classified as a class B drug under the Misuse of Drugs Act 1971 since 10 June 2014.
See also [ edit ]
References [ edit ]
^ a b Casale JF, McKibben TD, Bozenko JS, Hays PA (2005). "Characterization of the "Indanylamphetamines. "" Microgram Journal 3 (1–2): 3–10.
^ a b c Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE (November 1993). "Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine". Journal of Medicinal Chemistry 36 (23): 3700–6. doi: 10.1021/jm00075a027. PMID 8246240.
^ a b Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE (March 1998). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry 41 (6): 1001–5. doi: 10.1021/jm9705925. PMID 9526575.
External links [ edit ]
5-HT 2AR agonists
5-MeO-2, N, N-TMT
5-MeO-4, N, N-TMT
5- N, N-TMT