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5C or 5c may refer to:
- 5C Situation analysis: Company, Competitors, Customers, Collaborators, Climate
- 5-C (Five County), an Idaho juvenile detention center for high-risk individuals
- CAL Cargo Air Lines IATA code
- Chromosome Conformation Capture Carbon Copy, or 5C, an extension of the Chromosome conformation capture (3C) method used in genomics
- Fifth Cambridge Survey of Radio Sources
- Five Cs of Singapore, a cultural term relating to materialism
- Five-cent coin
- The consortium of the five Claremont Colleges
- Five Company (5C) Digital Transmission Content Protection
- The Apple iPhone 5c
- 5C, the production code for the 1978 Doctor Who serial The Stones of Blood
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