|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||270.375 g/mol g·mol−1|
|3D model (JSmol)|
|(what is this?)|
5-MeO-DALT binds to 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, α2A, α2B, α2C, H1, κ-opioid, σ1 and σ2 receptors with Ki values lower than 10μM and also acts as a DAT and SERT monoamine reuptake inhibitor.
|Binding site||pKi ± SEM at binding site|
|5-HT1A||7.70 ± 0.10|
|5-HT1B||6.13 ± 0.04|
|5-HT1D||7.00 ± 0.10|
|5-HT1E||6.30 ± 0.05|
|5-HT2A||6.66 ± 0.08|
|5-HT2B||7.23 ± 0.05|
|5-HT2C||6.34 ± 0.08|
|5-HT5A||5.48 ± 0.04|
|5-HT6||6.81 ± 0.03|
|5-HT7||7.05 ± 0.07|
|α2A||6.67 ± 0.07|
|α2B||6.14 ± 0.04|
|α2C||5.83 ± 0.06|
|H1||6.30 ± 0.06|
|H3||5.77 ± 0.04|
|κOR||5.95 ± 0.07|
|σ1||6.52 ± 0.06|
|σ2||6.60 ± 0.05|
|DAT||5.50 ± 0.20|
|SERT||6.30 ± 0.05|
The first material regarding the synthesis and effects of 5-MeO-DALT was sent from Alexander Shulgin to a research associate named Murple in May 2004, after which it was circulated online. In June 2004 5-MeO-DALT became available from internet research chemical vendors after being synthesized by commercial laboratories in China. In August 2004 the synthesis and effects of 5-MeO-DALT were published by Erowid.
Doses ranging from 12–20 mg were tested by Alexander Shulgin's research group.
There is no published literature on the toxicity of 5-MeO-DALT.
As of October 2015 5-MeO-DALT is a controlled substance in China.
5-MeO-DALT became a Class A drug in the UK on January 7th 2015 after an update to the tryptamine blanket ban.
5-MeO-DALT is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.
Sveriges riksdag added 5-MeO-DALT to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 5-MeO-DALT N-allyl-N-[2-(5-metoxi-1H-indol-3-yl)etyl]-prop-2-en-1-amin.
5-MeO-DALT is not scheduled at the federal level in the United States, but it is likely that it could be considered an analog of 5-Meo-DiPT or another tryptamine, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.
- Nicholas V. Cozzi; Paul F. Daley (December 2015). "Receptor binding profiles and quantitative structure-affinity relationships of some 5–substituted-N,N-diallyltryptamines". Bioorganic & Medicinal Chemistry Letters. 26 (3): 959–964. doi:10.1016/j.bmcl.2015.12.053. PMID 26739781.
- Julian A. Michely; Andreas G. Helfer; Simon D. Brandt; Markus R. Meyer; Hans H. Maurer (August 2015). "Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC–MS, LC–MS n , and LC–HR–MS–MS" (PDF). Analytical and Bioanalytical Chemistry. 407 (25): 7831–42. doi:10.1007/s00216-015-8955-0. PMID 26297461.
- Julia Dinger; Campbell Woods; Simon D. Brandt; Markus R. Meyer; Hans H. Maurer (January 2016). "Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class" (PDF). Toxicology Letters. 241: 82–94. doi:10.1016/j.toxlet.2015.11.013. PMID 26599973.
- Hamilton Morris; Ash Smith (2 May 2010). "The Last Interview With Alexander Shulgin". Vice. Retrieved 3 September 2015.
- "Sasha Shulgin - 5-MeO-DALT, 2C-B-FLY & 5-EtOs". Retrieved 3 September 2015.
- "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
- "厚生労働省：平成１8年度無承認無許可医薬品等買上調査の結果について" (in Japanese). Retrieved 24 July 2015.
- "CNB NEWS RELEASE". Central Narcotics Bureau (CNB). 30 April 2015. Archived from the original on 15 July 2015. Retrieved 24 July 2015.
- Generaldirektör Christina Rångemark Åkerman (20 April 2012). "Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika" (PDF) (in Swedish). Retrieved 3 September 2015.
- §1308.11 Schedule I.
- Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL
- "Louisiana State Legislature". Retrieved 3 September 2015.