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CAS Number 2454-70-8 N
PubChem CID 417608
ChemSpider 369669 YesY
Chemical data
Formula C15H22N2O
Molar mass 246.36 g/mol
 NYesY (what is this?)  (verify)

5-MeO-DET or 5-methoxy-N,N-diethyltryptamine is a hallucinogenic tryptamine.


5-MeO-DET inhibits serotonin reuptake with an IC50 value of 2.4 µM and activates 5-HT2A receptors with an EC50 value of 8.11 nM.[1][2][3][4][5][6][7]


Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects. Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions.

See also[edit]


  1. ^ Meike Schulze-Alexandru; Karl-Artur Kovar; Angelo Vedani (December 1999). "Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR Study on Hallucinogenic Substances". Quantitative Structure-Activity Relationships 18 (6): 548–560. doi:10.1002/(SICI)1521-3838(199912)18:6<548::AID-QSAR548>3.0.CO;2-B. 
  2. ^ Michael B. Gatch; Michael J. Forster; Aaron Janowsky; Amy J. Eshleman (April 2011). "Abuse Liability Profile of Three Substituted Tryptamines". Journal of Pharmacology and Experimental Therapeutics 338 (1): 280–289. doi:10.1124/jpet.111.179705. 
  3. ^ Richard A. Glennon; Peter K. Gessner (April 1979). "Serotonin receptor binding affinities of tryptamine analogs". Journal of Medicinal Chemistry 22 (4): 428–432. doi:10.1021/jm00190a014. PMID 430481. 
  4. ^ Adam L. Halberstadt; Mark A. Geyer (September 2011). "Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens". Neuropharmacology 61 (3): 364–381. doi:10.1016/j.neuropharm.2011.01.017. PMC 3110631. PMID 21256140. 
  5. ^ P.K. Gessner; D.D. Godse; A.H. Krull; J.M. McMullan (March 1968). "Structure-activity relationships among 5-methoxy-N:N-dimethyltryptamine, 4-hydroxy-N:N-dimethyltryptamine (psilocin) and other substituted tryptamines". Life Sciences 7 (5): 267–277. doi:10.1016/0024-3205(68)90200-2. 
  6. ^ Robert A. Lyon; Milt Titeler; Mark R. Seggel; Richard A. Glennon (January 1988). "Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens". European Journal of Pharmacology 145 (3): 291–297. doi:10.1016/0014-2999(88)90432-3. PMID 3350047. 
  7. ^ Bruce E. Blough; Antonio Landavazo; Ann M. Decker; John S. Partilla; Michael H. Baumann; Richard B. Rothman (October 2014). "Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes". Psychopharmacology 231 (21): 4135–4144. doi:10.1007/s00213-014-3557-7. PMID 24800892. 

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