Class of enzymes
5-formyltetrahydrofolate cyclo-ligase Identifiers Aliases methenyl-THF synthetase5,10-methenyltetrahydrofolate synthetase5-formyltetrahydrofolate cyclo-ligase (ADP-forming)5-Formyltetrahydrofolate cyclodehydraseformyltetrahydrofolic cyclodehydraseExternal IDs OMIM : 604197 GeneCards : [1] Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) n/a n/a PubMed search[1] n/a Wikidata
In enzymology , a 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2 ) is an enzyme that catalyzes the chemical reaction
ATP + 5-formyltetrahydrofolate (folinic acid)
⇌
{\displaystyle \rightleftharpoons }
ADP + phosphate + 5,10-methenyltetrahydrofolate
Thus, the two substrates of this enzyme are ATP and 5-formyltetrahydrofolate , whereas its 3 products are ADP , phosphate , and 5,10-methenyltetrahydrofolate .
This enzyme belongs to the family of ligases , specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 5-formyltetrahydrofolate cyclo-ligase (ADP-forming) . Other names in common use include 5,10-methenyltetrahydrofolate synthetase (MTHFS), formyltetrahydrofolic cyclodehydrase , and 5-formyltetrahydrofolate cyclodehydrase . This enzyme participates in one carbon pool by folate .
Structural studies [ edit ]
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1SBQ , 1SOU , 1U3F , 1U3G , and 2JCB .
Role in pathology [ edit ]
Mutations of the MTHFS gene cause the disease 5,10-methenyltetrahydrofolate synthetase deficiency .
References [ edit ]
Greenberg DM, Wynston LK, Nagabhushanan A (1965). "Further studies on N5-formyltetrahydrofolic acid cyclodehydrase". Biochemistry . 4 (9): 1872–1878. doi :10.1021/bi00885a026 .
6.1 : Carbon-Oxygen6.2 : Carbon-Sulfur6.3 : Carbon-Nitrogen
Activity Regulation Classification Kinetics Types