5.8S ribosomal RNA

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5.8S ribosomal RNA
Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA
Symbol 5_8S_rRNA
Rfam RF00002
Other data
RNA type Gene; rRNA
Domain(s) Eukaryota; Archaea
GO 0003735 0005840
SO 0000375

In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2]

5.8S rRNA can be used as a reference gene for miRNA detection.[3]


  1. ^ Abou, Elela S; Nazar RN (1997). "Role of the 5.8S rRNA in ribosome translocation". Nucleic Acids Res. 25 (9): 1788–1794. doi:10.1093/nar/25.9.1788. PMC 146658Freely accessible. PMID 9108162. 
  2. ^ Fontoura, BM; Atienza CA; Sorokina EA; Morimoto T; Carroll RB (1997). "Cytoplasmic p53 polypeptide is associated with ribosomes". Mol Cell Biol. 17 (6): 3146–3154. PMC 232167Freely accessible. PMID 9154813. 
  3. ^ Shi R, Chiang VL (October 2005). "Facile means for quantifying microRNA expression by real-time PCR". BioTechniques. 39 (4): 519–25. doi:10.2144/000112010. PMID 16235564. Retrieved 2010-09-15. 

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