5.8S ribosomal RNA
|5.8S ribosomal RNA|
|Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA|
|RNA type||Gene; rRNA|
In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in ribosome translocation. It is also known to form covalent linkage to the p53 tumour suppressor protein. 5.8S rRNA is also found in archaea.
- Abou, Elela S; Nazar RN (1997). "Role of the 5.8S rRNA in ribosome translocation". Nucleic Acids Res 25 (9): 1788–1794. doi:10.1093/nar/25.9.1788. PMC 146658. PMID 9108162.
- Fontoura, BM; Atienza CA; Sorokina EA; Morimoto T; Carroll RB (1997). "Cytoplasmic p53 polypeptide is associated with ribosomes". Mol Cell Biol 17 (6): 3146–3154. PMC 232167. PMID 9154813.
- Shi R, Chiang VL (October 2005). "Facile means for quantifying microRNA expression by real-time PCR". BioTechniques 39 (4): 519–25. doi:10.2144/000112010. PMID 16235564. Retrieved 2010-09-15.
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