|Centuries:||5th century – 6th century – 7th century|
|Decades:||510s 520s 530s – 540s – 550s 560s 570s|
|Years:||543 544 545 – 546 – 547 548 549|
|546 by topic|
|State leaders – Sovereign states|
|Birth and death categories|
|Births – Deaths|
|Establishment and disestablishment categories|
|Establishments – Disestablishments|
|Ab urbe condita||1299|
|Chinese calendar||乙丑年 (Wood Ox)
3242 or 3182
— to —
丙寅年 (Fire Tiger)
3243 or 3183
|- Vikram Samvat||602–603|
|- Shaka Samvat||467–468|
|- Kali Yuga||3646–3647|
|Iranian calendar||76 BP – 75 BP|
|Islamic calendar||78 BH – 77 BH|
|Minguo calendar||1366 before ROC
|Seleucid era||857/858 AG|
|Thai solar calendar||1088–1089|
Year 546 (DXLVI) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. The denomination 546 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
- December 17 – Sack of Rome: After almost a year's siege, capture of a grain fleet sent by the exiled Pope Vigilius near the mouth of the Tiber and failure of troops of the Byzantine Empire under Belisarius to relieve the city, the Ostrogoths under king Totila plunder Rome and destroy its fortifications. He then withdraws to Apulia (Southern Italy).
- Winter – Pope Vigilius arrives in Constantinople to meet with emperor Justinian I. The future pope Pelagius is sent by Totila to negotiate with Justinian.
- Audoin succeeds Walthari as king of the Lombards. In order to gain the throne for himself he murders Walthari.
- Audoin receives subsidies, Justinian I encourages him to battle the Gepids in the Carpathian Mountains.
- Audoin leads the Lombards across the Danube into Pannonia and becomes an ally of the Byzantines.
- Aj Wosal is leader of Naranjo following its conquest by Calakmul during the First Tikal-Calakmul War.
- The Basilica of San Vitale (Ravenna) is completed by bishop Maximianus during the Byzantine Exarchate of Ravenna.
- Approximate date – The Diocese of Bangor is established in the Welsh kingdom of Gwynedd with Deiniol consecrated as first bishop.