5F-PB-22

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5F-PB-22
5F-PB-22.png
Systematic (IUPAC) name
1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
Clinical data
Legal status
Identifiers
CAS Registry Number 1400742-41-7
ChemSpider 29341631
Chemical data
Formula C23H21FN2O2
Molecular mass 376.42 g/mol

5F-PB-22 or Quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate is a designer drug which acts as a cannabinoid agonist.[1] The structure of 5F-PB-22 appears to have been designed with an understanding of structure-activity relationships within the indole class of cannabinoids.[2]

In January 2014, 5F-PB-22 was designated as a Schedule I controlled substance in the United States after several deaths were associated with its use.[3][4]


See also[edit]

References[edit]

  1. ^ Banister, S. D.; Stuart, J.; Kevin, R. C.; Edington, A.; Longworth, M.; Wilkinson, S. M.; Beinat, C.; Buchanan, A. S.; Hibbs, D. E.; Glass, M.; Connor, M.; McGregor, I. S.; Kassiou, M. (2015). "Effects of Bioisosteric Fluorine in Synthetic Cannabinoid Designer Drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135". ACS Chemical Neuroscience: 150508124201002. doi:10.1021/acschemneuro.5b00107.  edit
  2. ^ "5F-PB-22". Forendex. Retrieved 24 June 2015. 
  3. ^ Behonick, G; Shanks, K. G.; Firchau, D. J.; Mathur, G; Lynch, C. F.; Nashelsky, M; Jaskierny, D. J.; Meroueh, C (2014). "Four Postmortem Case Reports with Quantitative Detection of the Synthetic Cannabinoid, 5F-PB-22". Journal of analytical toxicology 38: 559–62. doi:10.1093/jat/bku048. PMID 24876364.  edit
  4. ^ Jordan Trecki, Roy R. Gerona, Michael D. Schwartz (July 2015). "Synthetic Cannabinoid–Related Illnesses and Deaths". New England Journal of Medicine 373 (2): 103–107. doi:10.1056/NEJMp1505328. PMID 26154784.