From Wikipedia, the free encyclopedia
  (Redirected from 6',7'-dihydroxybergamottin)
Jump to: navigation, search
3D model (JSmol)
Molar mass 372.42 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

6',7'-Dihydroxybergamottin is a natural furanocoumarin found principally in grapefruit juice.[1] Along with the chemically related compound bergamottin, it is believed to be responsible for a number of grapefruit–drug interactions, in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.[2][3]


  1. ^ Edwards, D.J.; F.H Bellevue, 3rd; P.M. Woster (December 1996). "Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice". Drug Metabolism & Disposition. 24 (12): 1287–1290. 
  2. ^ David G. Bailey; J. Malcolm; O. Arnold; J. David Spence (1998). "Grapefruit juice-drug interactions". Br J Clin Pharmacol. 46 (2): 101–110. PMC 1873672Freely accessible. PMID 9723817. doi:10.1046/j.1365-2125.1998.00764.x. 
  3. ^ Girennavar, Basavaraj; Poulose, Shibu M.; Jayaprakasha, Guddadarangavvanahally K.; Bhat, Narayan G.; Patil, Bhimanagouda S. (2006). "Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes". Bioorganic & Medicinal Chemistry. 14 (8): 2606–2612. ISSN 0968-0896. PMID 16338240. doi:10.1016/j.bmc.2005.11.039.