60S ribosomal protein L28

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RPL28
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPL28, L28, ribosomal protein L28
External IDs MGI: 101839 HomoloGene: 768 GeneCards: RPL28
EC number 3.6.5.3
RNA expression pattern
PBB GE RPL28 213223 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000991
NM_001136134
NM_001136135
NM_001136136
NM_001136137

NM_009081

RefSeq (protein)

NP_000982
NP_001129606
NP_001129607
NP_001129608
NP_001129609

NP_033107.1
NP_033107

Location (UCSC) Chr 19: 55.39 – 55.4 Mb Chr 7: 4.79 – 4.8 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.[3][4][5]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601. 
  4. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194. 
  5. ^ a b "Entrez Gene: RPL28 ribosomal protein L28". 

External links[edit]

Further reading[edit]