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6S may stand for:
- 6S (music), key signature of six sharps
- 6S (radiative transfer code), a computer program that simulates the reflection of solar radiation
- 6S / SsrS RNA, the first noncoding RNA to be sequenced
- 6S, a modification of the 5S methodology which includes "Safety" as the 6th S. It is a lean process improvement tool that stands for Sort, Set in Order (aka Straighten or Stabilize), Shine (aka Scrub or Sweep), Standardize, Sustain, Safety.
- 6S can be the shortened form of Six Sigma
- iPhone 6S
- Kato Airline, a Norwegian airline with an IATA airline designator of 6S from 1996 to 2008
- Sahara Airlines (Algeria), an Algerian airline with an IATA airline designator of 6S from 1999 to 2003
- Star Air Aviation, a Pakistani airline with an IATA airline designator of 6S
- British Rail Class 201 diesel-electric multiple units with 6 coaches and a short frame (6S)
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