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Stereo, Kekulé, skeletal formula of 7-hydroxymitragynine with an explicit hydrogen added
IUPAC name
Methyl (E)-2-[(2S,3S,7aS,12bS)-3-ethyl-7a-hydroxy-8-methoxy-2,3,4,6,7,12b-hexahydro-1H-indolo[2,3-a]quinolizin-2-yl]-3-methoxyprop-2-enoate
Other names
7α-Hydroxy-7H-mitragynine;[1] 9-Methoxycorynantheidine hydroxyindolenine[1]
3D model (JSmol)
Molar mass 414.502 g·mol−1
log P 1.266
Acidity (pKa) 12.203
Basicity (pKb) 1.794
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

7-Hydroxymitragynine is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as Kratom.[2] It is often referred to as ‘7-OH’ and it first described in 1994[3] and is a natural product derived from the mitragynine present in the Kratom leaf. It is considered as oxidized derivative of mitragynine.[4]


See also[edit]


  1. ^ a b Chemical Abstracts Service: Columbus, OH, 2004; RN 174418-82-7 (accessed via SciFinder Scholar, version 2007.3; November 30, 2011)
  2. ^ Matsumoto K, Horie S, Ishikawa H, Takayama H, Aimi N, Ponglux D, Watanabe K (March 2004). "Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa". Life Sciences. 74 (17): 2143–55. doi:10.1016/j.lfs.2003.09.054. PMID 14969718.
  3. ^ Ponglux, Dhavadee; Wongseripipatana, Sumphan; Takayama, Hiromitsu; Kikuchi, Masae; Kurihara, Mika; Kitajima, Mariko; Aimi, Norio; Sakai, Shin-ichiro (1994). "A New Indole Alkaloid, 7 α-Hydroxy-7H-mitragynine, fromMitragyna speciosain Thailand". Planta Medica. 60 (6): 580–581. doi:10.1055/s-2006-959578. ISSN 0032-0943. PMID 17236085.
  4. ^ "7-Hydroxymitragynine - Green Leaf Kratom - Kratom Blogs Archives". Green Leaf Kratom. 2020-08-19. Retrieved 2020-08-22.

External links[edit]