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Molar mass403.478 g·mol−1
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7-Spiroindanyloxymorphone (SIOM) is a drug that is used in scientific research. It is a selective δ-opioid agonist. It is a derivative of oxymorphone.[1][2][3][4][5]


  1. ^ Portoghese PS, Moe ST, Takemori AE (August 1993). "A selective delta 1 opioid receptor agonist derived from oxymorphone. Evidence for separate recognition sites for delta 1 opioid receptor agonists and antagonists". Journal of Medicinal Chemistry. 36 (17): 2572–4. doi:10.1021/jm00069a017. PMID 8394935.
  2. ^ Fang X, Larson DL, Portoghese PS (September 1997). "7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands". Journal of Medicinal Chemistry. 40 (19): 3064–70. doi:10.1021/jm970283e. PMID 9301669.
  3. ^ Ohkawa S, DiGiacomo B, Larson DL, Takemori AE, Portoghese PS (May 1997). "7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors". Journal of Medicinal Chemistry. 40 (11): 1720–5. doi:10.1021/jm9700880. PMID 9171881.
  4. ^ Kshirsagar TA, Fang X, Portoghese PS (July 1998). "14-Desoxy analogues of naltrindole and 7-spiroindanyloxymorphone: the role of the 14-hydroxy group at delta opioid receptors". Journal of Medicinal Chemistry. 41 (14): 2657–60. doi:10.1021/jm980209b. PMID 9651172.
  5. ^ Shenderovich MD, Liao S, Qian X, Hruby VJ (June 2000). "A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands". Biopolymers. 53 (7): 565–80. doi:10.1002/(SICI)1097-0282(200006)53:7<565::AID-BIP4>3.0.CO;2-5. PMID 10766952.