WARS2

WARS2
Identifiers
Aliases	WARS2, TrpRS, tryptophanyl tRNA synthetase 2, mitochondrial, NEMMLAS, mtTrpRS, PKDYS3
External IDs	OMIM: 604733; MGI: 1917810; HomoloGene: 5673; GeneCards: WARS2; OMA:WARS2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p12 Start 119,031,216 bp End 119,140,654 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F2.2 Start 99,048,384 bp End 99,146,502 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad bronchial epithelial cell Achilles tendon testicle parietal pleura right adrenal cortex tibia left adrenal gland body of pancreas left adrenal cortex Top expressed in morula submandibular gland urethra endocardial cushion medullary collecting duct gastrula blastocyst right kidney lumbar subsegment of spinal cord fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity ATP binding tryptophan-tRNA ligase activity Cellular component cytoplasm mitochondrion plasma membrane mitochondrial matrix Biological process vasculogenesis tryptophanyl-tRNA aminoacylation tRNA aminoacylation for protein translation protein biosynthesis mitochondrial tryptophanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10352 70560 Ensembl ENSG00000116874 ENSMUSG00000004233 UniProt Q9UGM6 Q9CYK1 RefSeq (mRNA) NM_015836 NM_201263 NM_001378226 NM_001378227 NM_001378228 NM_001378229 NM_001378230 NM_001378231 NM_027462 RefSeq (protein) NP_056651 NP_957715 NP_001365155 NP_001365156 NP_001365157 NP_001365158 NP_001365159 NP_001365160 NP_081738 Location (UCSC) Chr 1: 119.03 – 119.14 Mb Chr 3: 99.05 – 99.15 Mb PubMed search
Wikidata
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Tryptophanyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the WARS2 gene.

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Liu J, Shue E, Ewalt KL, Schimmel P (2004). "A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase". Nucleic Acids Res. 32 (2): 719–27. doi:10.1093/nar/gkh240. PMC 373357. PMID 14757836.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Guo LT, Chen XL, Zhao BT, Shi Y, Li W, Xue H, Jin YX (2007). "Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311". Nucleic Acids Res. 35 (17): 5934–43. doi:10.1093/nar/gkm633. PMC 2034488. PMID 17726052.

External links

• WARS2 human gene location in the UCSC Genome Browser.
• WARS2 human gene details in the UCSC Genome Browser.