MAP4K2

MAP4K2
Identifiers
Aliases	MAP4K2, BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
External IDs	OMIM: 603166; MGI: 1346883; HomoloGene: 3370; GeneCards: MAP4K2; OMA:MAP4K2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 64,784,918 bp End 64,803,241 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 6,391,165 bp End 6,405,645 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen right lung monocyte right hemisphere of cerebellum lymph node gonad right frontal lobe upper lobe of left lung prefrontal cortex Top expressed in granulocyte thymus Cerebellum spleen cerebellar cortex neural layer of retina Hypothalamus striatum of neuraxis primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity mitogen-activated protein kinase kinase kinase binding kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase kinase activity Cellular component Golgi apparatus membrane Golgi membrane plasma membrane basolateral plasma membrane cytoplasm Biological process intracellular signal transduction vesicle targeting phosphorylation immune system process positive regulation of JNK cascade protein phosphorylation JNK cascade immune response innate immune response regulation of mitotic cell cycle regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5871 26412 Ensembl ENSG00000168067 ENSMUSG00000024948 UniProt Q12851 Q61161 RefSeq (mRNA) NM_001307990 NM_004579 NM_001291787 NM_009006 RefSeq (protein) NP_001294919 NP_004570 NP_001278716 NP_033032 Location (UCSC) Chr 11: 64.78 – 64.8 Mb Chr 19: 6.39 – 6.41 Mb PubMed search
Wikidata
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Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.

Function

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. A recent study showed that MAP4K2 is a direct kinase of LATS1/2 and thus regulates the Hippo pathway effectors YAP and TAZ.

Interactions

MAP4K2 has been shown to interact with RAB8A and TRAF2.

Further reading

• Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P (Apr 1992). "Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus". Nature. 356 (6371): 721–2. Bibcode:1992Natur.356..721V. doi:10.1038/356721a0. PMID 1570017. S2CID 4310834.
• Matsutani A, Janssen R, Donis-Keller H, Permutt MA (Feb 1992). "A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p". Genomics. 12 (2): 319–25. doi:10.1016/0888-7543(92)90380-B. PMID 1740341.
• Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM (Oct 1995). "Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase". Nature. 377 (6551): 750–4. Bibcode:1995Natur.377..750P. doi:10.1038/377750a0. PMID 7477268. S2CID 4328522.
• Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. Bibcode:1996PNAS...93.5151R. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.
• Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (Jul 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
• Yuasa T, Ohno S, Kehrl JH, Kyriakis JM (Aug 1998). "Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38". The Journal of Biological Chemistry. 273 (35): 22681–92. doi:10.1074/jbc.273.35.22681. PMID 9712898.
• Chadee DN, Yuasa T, Kyriakis JM (Feb 2002). "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2". Molecular and Cellular Biology. 22 (3): 737–49. doi:10.1128/MCB.22.3.737-749.2002. PMC 133545. PMID 11784851.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (Mar 2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Molecular & Cellular Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.