Somatostatin receptor 5

SSTR5
Identifiers
Aliases	SSTR5, SS-5-R, Somatostatin receptor 5
External IDs	MGI: 894282; HomoloGene: 20287; GeneCards: SSTR5; OMA:SSTR5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,072,747 bp End 1,081,454 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 12.62 cM Start 25,708,849 bp End 25,716,262 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle apex of heart anterior pituitary right adrenal cortex left ventricle Descending thoracic aorta left adrenal cortex ascending aorta right coronary artery metanephros Top expressed in embryo embryo choroid plexus of fourth ventricle soleus muscle entorhinal cortex superior frontal gyrus primary motor cortex superior colliculus basal forebrain striatum of neuraxis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding G protein-coupled receptor activity signal transducer activity somatostatin receptor activity peptide binding Cellular component integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process positive regulation of cytokinesis G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger glucose homeostasis signal transduction negative regulation of cell population proliferation regulation of insulin secretion somatostatin signaling pathway chemical synaptic transmission cellular response to glucocorticoid stimulus neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6755 20609 Ensembl ENSG00000162009 ENSMUSG00000050824 UniProt P35346 O08858 RefSeq (mRNA) NM_001053 NM_001172560 NM_001172572 NM_001172573 NM_001191008 NM_011425 RefSeq (protein) NP_001044 NP_001166031 NP_001177937 NP_035555 Location (UCSC) Chr 16: 1.07 – 1.08 Mb Chr 17: 25.71 – 25.72 Mb PubMed search
Wikidata
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Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. Bibcode:1992PNAS...89..251Y. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. Bibcode:1984PNAS...81.3337M. doi:10.1073/pnas.81.11.3337. PMC 345502. PMID 6145156.
• Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Mol. Pharmacol. 45 (3): 417–27. PMID 7908405.
• O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Mol. Pharmacol. 46 (2): 291–8. PMID 8078491.
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. doi:10.1210/jcem.82.6.4013. PMID 9177396. S2CID 25337792.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525. S2CID 23503397.
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi:10.1074/jbc.273.33.21416. PMID 9694905.
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi:10.1210/mend.13.1.0220. PMID 9892014.
• Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID 9892225.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. doi:10.1074/jbc.275.11.7862. PMID 10713101.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463): 154–7. Bibcode:2000Sci...288..154R. doi:10.1126/science.288.5463.154. PMID 10753124.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. doi:10.1210/jcem.86.8.7787. PMID 11502816. S2CID 17616592.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920. S2CID 28584328.

External links

• "Somatostatin Receptors: sst₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• somatostatin+receptor+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.