RCBTB2

RCBTB2
Identifiers
Aliases	RCBTB2, CHC1L, RLG, RCC1 and BTB domain containing protein 2
External IDs	OMIM: 603524; MGI: 1917200; HomoloGene: 970; GeneCards: RCBTB2; OMA:RCBTB2 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	48,533,256 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	73,445,283 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; monocyte; ; optic nerve; ; parietal pleura; ; visceral pleura; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; seminal vesicula; ; ganglionic eminence; ; ventricular zone;
	Top expressed in
	otic vesicle; ; saccule; ; otic placode; ; mandibular prominence; ; thymus; ; maxillary prominence; ; somite; ; ventricular zone; ; brown adipose tissue; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	acrosomal vesicle; cytoplasmic vesicle;
Biological process	regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	1102
	105670
	ENSG00000136161
	ENSMUSG00000022106
	O95199
	Q99LJ7
NM_001268; NM_001286830; NM_001286831; NM_001286832; NM_001352424;
	NM_001352425; NM_001352426; NM_001352427; NM_001352428; NM_001352429; NM_001352430; NM_001352431
	NM_001170694; NM_134083
NP_001259; NP_001273759; NP_001273760; NP_001273761; NP_001339353;
	NP_001339354; NP_001339355; NP_001339356; NP_001339357; NP_001339358; NP_001339359; NP_001339360
	NP_001164165; NP_598844
	Wikidata
View/Edit Human	View/Edit Mouse

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.^[5]^[6]

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136161 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022106 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.
^ ^a ^b "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Latil A, Morant P, Fournier G, et al. (2002). "CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer". Int. J. Cancer. 99 (5): 689–96. doi:10.1002/ijc.10393. PMID 12115502. S2CID 36595791.
Renault L, Nassar N, Wittinghofer A, et al. (1999). "Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation". Acta Crystallogr. D. 55 (Pt 1): 272–5. doi:10.1107/S0907444998007768. PMID 10089422.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136161 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022106 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806834-5] Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP (Jan 1999). "cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor". Genomics. 54 (1): 99–106. doi:10.1006/geno.1998.5498. PMID 9806834.

[entrez-6] "Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2".

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References

Further reading